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1st place
Bellarmine College Preparatory - San Jose, CA
Back row left to right: Patrick Adams (coach), Tamara Currier (Toshiba) Front row left to right: Nithin Buduma, Natalie Ng, Nikhil Buduma, Alexander Powers Photo credit: Sheila Collison
Bellarmine College Preparatory — San Jose, CA

Immunotargeted DNA-based nanostructures for the delivery of the pro-angiogenic VEGF protein to revascularize infarcted myocardium

Immunotargeted DNA nanostructures integrate DNA "origami" and antibody-based specificity to revascularize damaged heart tissue after a heart attack. This two-component delivery mechanism allows for the specific targeting of the angiogenic VEGF protein directly to the site of injury. Revascularization of infarcted myocardium will make stem cell therapy a viable treatment for heart attacks. This flexible delivery design can also be easily applied to target any therapeutic to any cell population in the human body.

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