An estimated 35-40 million people require prosthetics and orthotic devices. Neuroprosthetics utilize brain-computer interfaces (BCIs) to record and analyze neural signals, enabling patients to cognitively control an external prosthetic. Unfortunately, wireless invasive BCIs, the most accurate, rely on craniotomy for insertion, which can cause brain damage. Nanocarriers are often used for targeted drug delivery, encasing therapeutics in their core for transport and release. Our solution, N4NO (Nanocarriers for Neuroprosthetic Optimization), provides a minimally invasive method of inserting neural dust “motes”, an extremely small BCI. Polymeric micelle nanocarriers deliver these motes to a specific location in the brain via cerebrospinal fluid through intrathecal injection. Once released, the mote attached to a self-folding cuff wraps around a specific nerve, enabling accurate recording of brain activity and nerve stimulation. Using neurofeedback and AI modeling, patients would be able to exhibit seamless neuroprosthetic control, improving their quality of life without the dangers of craniotomy.