Immunotargeted DNA-based nanostructures for the delivery of the pro-angiogenic VEGF protein to revascularize infarcted myocardium
Immunotargeted DNA nanostructures integrate DNA “origami” and antibody-based specificity to revascularize damaged heart tissue after a heart attack. This two-component delivery mechanism allows for the specific targeting of the angiogenic VEGF protein directly to the site of injury. Revascularization of infarcted myocardium will make stem cell therapy a viable treatment for heart attacks. This flexible delivery design can also be easily applied to target any therapeutic to any cell population in the human body.
